The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may perhaps lead to an increase in methadone plasma concentrations, which could lead to likely fatal respiratory depression. Also, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may result in an increase in … Read More